Abstract
The advantages of free threshing in wheat led to the selection of the domesticated Q allele, which is now present in almost all modern wheat varieties. Q and the pre-domestication allele, q, encode an AP2 transcription factor, with the domesticated allele conferring a free-threshing character and a subcompact (i.e. partially compact) inflorescence (spike). We demonstrate that mutations in the miR172 binding site of the Q gene are sufficient to increase transcript levels via a reduction in miRNA-dependent degradation, consistent with the conclusion that a single nucleotide polymorphism in the miRNA binding site of Q relative to q was essential in defining the modern Q allele. We describe novel gain- and loss-of-function alleles of Q and use these to define new roles for this gene in spike development. Q is required for the suppression of ‘sham ramification’, and increased Q expression can lead to the formation of ectopic florets and spikelets (specialized inflorescence branches that bear florets and grains), resulting in a deviation from the canonical spike and spikelet structures of domesticated wheat.
| Original language | English |
|---|---|
| Pages (from-to) | 1959-1965 |
| Number of pages | 7 |
| Journal | Development (Cambridge) |
| Volume | 144 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2017 |
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Greenwood, J. R., Finnegan, E. J., Watanabe, N., Trevaskis, B., & Swain, S. M. (2017). New alleles of the wheat domestication gene Q reveal multiple roles in growth and reproductive development. Development (Cambridge), 144(11), 1959-1965. https://doi.org/10.1242/dev.146407
Greenwood, Julian R. ; Finnegan, E. Jean ; Watanabe, Nobuyoshi et al. / New alleles of the wheat domestication gene Q reveal multiple roles in growth and reproductive development. In: Development (Cambridge). 2017 ; Vol. 144, No. 11. pp. 1959-1965.
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title = "New alleles of the wheat domestication gene Q reveal multiple roles in growth and reproductive development",
abstract = "The advantages of free threshing in wheat led to the selection of the domesticated Q allele, which is now present in almost all modern wheat varieties. Q and the pre-domestication allele, q, encode an AP2 transcription factor, with the domesticated allele conferring a free-threshing character and a subcompact (i.e. partially compact) inflorescence (spike). We demonstrate that mutations in the miR172 binding site of the Q gene are sufficient to increase transcript levels via a reduction in miRNA-dependent degradation, consistent with the conclusion that a single nucleotide polymorphism in the miRNA binding site of Q relative to q was essential in defining the modern Q allele. We describe novel gain- and loss-of-function alleles of Q and use these to define new roles for this gene in spike development. Q is required for the suppression of {\textquoteleft}sham ramification{\textquoteright}, and increased Q expression can lead to the formation of ectopic florets and spikelets (specialized inflorescence branches that bear florets and grains), resulting in a deviation from the canonical spike and spikelet structures of domesticated wheat.",
keywords = "AP2, Domestication, Inflorescence, MicroRNA, Spike, Wheat",
author = "Greenwood, {Julian R.} and Finnegan, {E. Jean} and Nobuyoshi Watanabe and Ben Trevaskis and Swain, {Steve M.}",
note = "Publisher Copyright: {\textcopyright} 2017. Published by The Company of Biologists Ltd.",
year = "2017",
doi = "10.1242/dev.146407",
language = "English",
volume = "144",
pages = "1959--1965",
journal = "Development (Cambridge)",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "11",
}
Greenwood, JR, Finnegan, EJ, Watanabe, N, Trevaskis, B & Swain, SM 2017, 'New alleles of the wheat domestication gene Q reveal multiple roles in growth and reproductive development', Development (Cambridge), vol. 144, no. 11, pp. 1959-1965. https://doi.org/10.1242/dev.146407
New alleles of the wheat domestication gene Q reveal multiple roles in growth and reproductive development. / Greenwood, Julian R.; Finnegan, E. Jean; Watanabe, Nobuyoshi et al.
In: Development (Cambridge), Vol. 144, No. 11, 2017, p. 1959-1965.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - New alleles of the wheat domestication gene Q reveal multiple roles in growth and reproductive development
AU - Greenwood, Julian R.
AU - Finnegan, E. Jean
AU - Watanabe, Nobuyoshi
AU - Trevaskis, Ben
AU - Swain, Steve M.
N1 - Publisher Copyright:© 2017. Published by The Company of Biologists Ltd.
PY - 2017
Y1 - 2017
N2 - The advantages of free threshing in wheat led to the selection of the domesticated Q allele, which is now present in almost all modern wheat varieties. Q and the pre-domestication allele, q, encode an AP2 transcription factor, with the domesticated allele conferring a free-threshing character and a subcompact (i.e. partially compact) inflorescence (spike). We demonstrate that mutations in the miR172 binding site of the Q gene are sufficient to increase transcript levels via a reduction in miRNA-dependent degradation, consistent with the conclusion that a single nucleotide polymorphism in the miRNA binding site of Q relative to q was essential in defining the modern Q allele. We describe novel gain- and loss-of-function alleles of Q and use these to define new roles for this gene in spike development. Q is required for the suppression of ‘sham ramification’, and increased Q expression can lead to the formation of ectopic florets and spikelets (specialized inflorescence branches that bear florets and grains), resulting in a deviation from the canonical spike and spikelet structures of domesticated wheat.
AB - The advantages of free threshing in wheat led to the selection of the domesticated Q allele, which is now present in almost all modern wheat varieties. Q and the pre-domestication allele, q, encode an AP2 transcription factor, with the domesticated allele conferring a free-threshing character and a subcompact (i.e. partially compact) inflorescence (spike). We demonstrate that mutations in the miR172 binding site of the Q gene are sufficient to increase transcript levels via a reduction in miRNA-dependent degradation, consistent with the conclusion that a single nucleotide polymorphism in the miRNA binding site of Q relative to q was essential in defining the modern Q allele. We describe novel gain- and loss-of-function alleles of Q and use these to define new roles for this gene in spike development. Q is required for the suppression of ‘sham ramification’, and increased Q expression can lead to the formation of ectopic florets and spikelets (specialized inflorescence branches that bear florets and grains), resulting in a deviation from the canonical spike and spikelet structures of domesticated wheat.
KW - AP2
KW - Domestication
KW - Inflorescence
KW - MicroRNA
KW - Spike
KW - Wheat
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U2 - 10.1242/dev.146407
DO - 10.1242/dev.146407
M3 - Article
SN - 0950-1991
VL - 144
SP - 1959
EP - 1965
JO - Development (Cambridge)
JF - Development (Cambridge)
IS - 11
ER -
Greenwood JR, Finnegan EJ, Watanabe N, Trevaskis B, Swain SM. New alleles of the wheat domestication gene Q reveal multiple roles in growth and reproductive development. Development (Cambridge). 2017;144(11):1959-1965. doi: 10.1242/dev.146407
